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KMID : 0379119850130020125
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Korean Journal of Mycology
1985 Volume.13 No. 2 p.125 ~ p.125
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Studies on Constituents of the Higher Fungi of Korea (LI.) An Antitumor Component Extracted from Cultured Mycelia of Volvariella bombycina
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Abstract
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To find antitumor-components in the shake-cultured mycelia of Volvariella bombycina, the mycelia were extracted with hot water after the extract was dialyzed and freeze-dried, a protein-polysaccharide fraction was obtained and examined for antitumor activity against the solid form of sarcoma 180 in ICR mice. It showed 60.3% inhibition ratio at a dose of 20 ㎎/㎏/day for 10 days. When the antitumor component was examined for immuno-potentiating activity, it was found to increase macrophage accumulation in the peritoneal cavity and antibody production.
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KEYWORD
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